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Symbol
Name
ID

Sh2b3
SH2B adaptor protein 3
MGI:893598

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Leukocytosis	Hemophagocytosis	Acute leukemia	Acute myeloid leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Splenomegaly	Autoimmunity
Disease(s) Associated with SH2B3	Leukocytosis	Hemophagocytosis	Acute leukemia	Acute myeloid leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Splenomegaly	Autoimmunity
essential thrombocythemia
familial erythrocytosis 1
myelofibrosis
type 1 diabetes mellitus

Mouse Phenotypes

abnormal granulocyte differentiation

abnormal monocyte differentiation

enlarged spleen

spleen hyperplasia

myeloid hyperplasia

increased neutrophil cell number

increased granulocyte number

abnormal leukocyte cell number

decreased B cell number

increased B cell number

increased lymphocyte cell number

increased monocyte cell number

increased leukocyte cell number

spleen fibrosis

enlarged lymph nodes

Availability

Mouse Genotype

Sh2b3^tm1Paw/Sh2b3^tm1Paw

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23